IntegraGen Announces Its Research Showing the Connection between miR-31-3p Expression and cetuximub efficacy in patients with KRAS wild-type metastatic colorectal cancer as published on Oncotarget

Recently, IntegraGen, a company that specializes in breaking down the human genome to in an effort to produce pertinent and easily interpretable data that can be used in both academic and commercial purposes announced that their findings from a study inquiring into miR-31-3p expression in cancerous tumor samples that were collected from patients who had been enrolled in the NEW EPOC clinical trial had been published online on Oncotarget. The title of the paper being “Association between miR-31-3p expression and cetuximub efficacy in patients with KRAS wild-type metastatic colorectal cancer: a post-hoc analysis of the New EPOC trial”. The findings seemed to come to the conclusion that there is a connection between miR-31-3p expression and how effective the anti-EGFR treatment can be.

One of the co-authors of the study Professor John Bridgewater is a Medical Oncologist at University College London Cancer Institute. Prof. Bridgewater as one of the scientists who was heavily involved with the New EPOC Study said that the publication contains results showing that miR-31-3p expression levels in patients who have been diagnosed with RAS wild-type metastatic colorectal cancer can serve as a diagnostic tool that helps find patients who qualify for targeted anti-EGFR therapy.He further expressed his confidence that they will continue to further examine data from the New EPOC trial. This data is very important especially to clinicians as it provides the much needed additional understanding on customizing therapeutic approaches to improve treatment of patients who have come down with metastatic colorectal cancer.IntegraGen‘s Director of Molecular Diagnostics Yann Gaston-Mathé also said that the findings have given more credibility to the exercise of measuring miR-31-3p in cancerous tumors from patients who have been diagnosed with metastatic colorectal cancer.

Who is IntegraGen?

IntegraGen is an Evry Genopole based company that specializes in breaking down the human genome to in an effort to produce pertinent and easily interpretable data that can be used in both academic and private laboratories. By 2016, IntegraGen had generated over €6.0 million in revenues with a payroll of 38 employees. Its U.S. office is in Cambridge, Massachusetts.

About Oncotarget

Oncotarget is a free weekly peer-reviewed medical journal established in 2010 and published by Impact Journals. It covers research on all aspects of oncology. Oncotarget also includes articles on other subjects and fields of study in science and medicine such as Metabolism, Endocrinology, Neuroscience, the aging process, Microbiology, Cardiology, The Immunology System, Pharmacology Cell Biology, among others. Oncotarget is one of the most popular journals in the circles of Medicine and Science professionals as the source of up-to-the-minute news, research, and information on the aforementioned fields of study. This can be demonstrated by the simple fact that in the years 2015 and 2016, Oncotarget had an impact factor 5.008. Mikhail Blagosklonny a former professor at the Roswell Park Cancer Institute in New York and Andrei V. Gudkov of Roswell Park Cancer Institute are the editors-in-chief of Oncotarget. Roswell Park Cancer Institute is a cancer research and treatment center based Buffalo, New York founded by Dr. Roswell Park in 1898.

Don Ressler and Adam Goldenberg’s Fabletics Continues To Explore The Market

Majority of women have a difficulty finding an athletic wear of their choice that is fashionable and affordable. That is because there has been a wide gap in the functionality and fashion on women’s sportswear for quite some time. In 2010, Don Ressler and Adam Goldenberg noticed the rising demand for active wear and decided to give it a shot. They immediately co-founded Fabletics with the mission of providing beautiful looking women active wear that was fashionable, affordable and functional. Their fast move was because the demand for women’s athletic wear was not dropping anytime soon.

Ressler and Adam Goldenberg didn’t just come up with any athletic wear. They focused on revolutionary wear in line with the current fashion trends, thus giving women what they desired. Through research, they were able to identify problems facing women in sportswear across the globe which included costly athletic wear, and at times non-fitting.

Ressler worked with Kate Hudson as a cofound in Fabletics. Women sportswear had the challenge of branding with only a few companies targeting women with their brands. Kate’s active role in the media, excellent communication skills, friendly tone, confidence, and composure took Fabletics brand on another level. Kate represented the company by being its spokeswoman. She was able to establish strong client relationships, thus linking Fabletics to majority of the people. Kate still focuses on taking the Fabletics brand a notch higher both online and in person.

Despite a few challenges when starting Fabletics, Ressler was able to cut through complexity to ensure that the sportswear was comfortable. Through his determination and experience in the fashion industry, the company was able to create comfortable and high-quality clothing.

Fabletics was able to outsmart its competitors in the fashion industry by establishing a strong market both online and at the grassroots level. Their marketing strategies outdo the traditional retail marketing system. Other than online selling, Fabletics discounted their prices where clients would sign up for a Fabletics VIP on a monthly charge of $50. The clients would then receive discounted prices on clothing, get their items delivered free of charge and earn points on all items they buy.

The VIP model coupled with their appealing website contributed to increased revenue. The site has a quiz that helps women suggest their athletic wear choice. These strategies have set Fabletics on a higher level than their competitors.

Ressler ensured that women’s sportswear was fun by creating best fashion choices, enabling an efficient online shopping space and catering for busy women who’re working on their health and looks.

Fabletics looks forward to expanding in 2017 targeting the plus size women.

OSI Group Is Expanding Its Market Internationally

According to experts, international companies tend to be local. That means that it is not possible for an organization with branches in the US, Europe, and China to manage the one-size-fits-all operation. The management of a company can be affected by government regulation, talent pool, and cultural practices. In the food processing industry, the list of things to consider will include the consumer’s taste buds.

David McDonald is the president of OSI Group. David says that his company is in an excellent position such that they have an international network, basically with workers from the organization in the office or the branches across the globe. He adds that the company operates in an international operation meaning that they are a large scale company, but work with local management teams. The team is compassionate, and they understand the local culture and tastes well. That is due to the powers of global scale and efficiency together with local solutions.

OSI Group ventures to China market

OSI Group is a top supplier of value-added protein products like sausage links and beef patties with its headquarters in Aurora, Ill. The company also produces and supplies products such as sandwiches and pizza to prominent food stores and retail brands. OSI Group is a privately owned company operating more than 50 manufacturing facilities in about 17 countries. Currently, the company is employing its international-efficiency and local-solution strategy in expanding its territory in China. OSI Group has been running its facilities in China for the past two decades, and as the economy of the country grows, the presence of the company grows with it. The company runs eight manufacturing facilities and with two new facilities, which were opened recently. Without a doubt, this will make the OSI Group the largest poultry producer in the country.

McDonald says that the OSI Group focuses on the China market and it will continue to be the biggest and rapidly developing consumer market in the world. That is because the country has the power of population, which is growing more affluent. He adds that they work with some responsive clients in China who are experiencing tremendous growth and the company aims to keep up with them. On top of that, the company seeks to engage with their clients on time to talk about the services they are trying to offer or the ideas that they need to pursue.

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Contributions of Eric Pulier to the Technology World

Born in 1966, New Jersey, United States, Eric Pulier has already achieved what most of his age mates dream about. A quick glances at his early life and education background, one would tell that he was born to do great things. While still in high school, he developed an immense interest in computer programming and was regarded a guru in the field.

Right after clearing Teaneck High School, he joined Harvard University. While in this prestigious institution, programming became a complete part of him. Following his widespread knowledge, landed a position as writer in the institution’s newspaper publication, The Harvard Crimson. After graduation, he was promoted to be an editor for the same publication. It has been a smooth journey for him and has done tremendously well. He is definitely agreat achiever and a big dream with high targets in life. He has done so well.

Eric Pulier has perfected skills in various fields. He’s an accomplished author, a philanthropist, a public speaker and a successful entrepreneur. Above all, he’s a renowned technologist who has been involved in the formation of a string of companies around the world. Worth noting is that his efforts are not in vain since all the businesses he’s helped to start all still operational and profitable.

Also, he has authored a book titled, Understanding Enterprise, which stresses on the need to come up with fresh ideas and striving to acquire the right skills as a basis for achieving one’s goals in life. Through the book, Eric advises the young people who intend to bring a change in the technology world to invest their efforts and resources on long-term investments.

In `1991, Eric Pulier founded a company named People Doing Things (PDT). The company was a great blessing to the resident as it sought to address the various issues including health care and education using technology. For example, the initiative provided a remarkable platform for enabling children living with chronic illness to gain easy access to the health they needed. The use of technology was part of his humanitarian efforts at building a better world.

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Igor Cornelsen: A Brilliant Investor Success Story

When it comes to successful investing, Igor Cornelsen’s story is a journey that demonstrates insight, wisdom, and professional experience. Brazilian by birth, Igor Cornelsen is a highly successful investment banker and a trustworthy investing and financial advisor. He also doubles as a consultant, providing advice to bankers and investors from his successful banking and investment career proficiency. He helps them make the right long-term smart investments in a predominantly unstable stock market.

He is among Brazil’s most successful bankers and was in charge of leading and managing some of the largest banking organizations worldwide. As a banker, he helped manage a massive percentage of the country’s gross economy. While some may consider investing as a very risky business, Igor Cornelsen considers investment a hobby that he developed during his banking days.

Because of his invaluable experience working in both the banking and investment fields and knowledge of the financial industry, Igor guides his clients – individuals, groups, and institutions – with reliable advice to help them lessen the risks that come with intelligent investing decisions and those inherent in the stock market. He continues to help investors make profits, both in short and long-term investments. From time to time, he also urges investors to focus on damaged stocks.

Career Advancements

Cornelsen started his career as a banker in Brazil where he worked with various leading major banks in the country before retiring in 2010. In the course of his career in the banking industry, he held several high-ranking positions.

Currently, Igor Cornelsen is working as the proprietor of Bainbridge Investments Inc. since 2011. The firm is based in the Bahamas. Here, Igor focuses on entrepreneur skills and offering investment expertise. As an investment expert, he concentrates on discovering creative strategies of using stock markets to create future success. He also spends a lot his time in South Florida where he focuses on investing as a hobby.


Mikhail Blagosklonny: Oncologist And More

Mikhail Blagosklonny is more than just an oncologist. He is also a researcher, a professor and a philanthropist too. One of his goals in life is to one day be to ensure that every single person in the world will have easy access to the very best medical treatment out there regardless of each individual’s personal finances.

Professional Areas Of Study

Blagosklonny is very interested in the field of medical research. He prefers to focus his studies on the areas of aging and cancer. He is specifically interested in researching the relationship between the two subjects. He hopes to one day be able to determine just why cancer is more prevalent among adults who are past a specific age.

Present Work

He is currently focusing his work on research that he thinks will provide information that will be continuously useful to all those who work in the field of oncology. Additionally, Blagosklonny is reportedly still influencing the work of others not only as a field researcher and expert in oncology but also as a college professor. Some sources report that he serves as a source of inspiration to both his peers and to his pupils who hope to expand upon his current research in the near future.

Areas Of Special Interest

Within the general areas of cancer and aging Blagosklonny’s specific areas of interest have brought him no small amount of attention and interest in the medical field. His main goal is to not only to determine how to treat cancer in general but how to treat it in a manner that is painless, effective and less expensive when compared to the different methods of treating cancer now. Blagosklonny also hopes to discover how to destroy cancerous cells within the body without destroying any of the normal, healthy cells that are important to the recovery of the mind and body after the many months or in perhaps even years of cancer treatment.

Blagosklonny’s Progress

As this goes to press, Mikhail Blagosklonny has made significant progress in his areas of interest. His wish is that his various discoveries will continue to both encourage and inspire others to follow in his footsteps and pick up where he will someday leave off. He believes that sometime in the future, the best cancer treatment will no longer be an expensive luxury for those who can afford it, but will be easy, painless, cost-effective, and readily available to anyone who needs it.

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Eric Pulier: A Man of Many Talents

Being gifted is something most people wish they were. Though we all live different lives, we are still very much similar. Talent comes in many forms whether it’s intellect or strictly being physical. We are all good at something, but if people can use their gifts to better man-kind the world would be a much better place. Case In Point: You may have never heard of a guy named Eric Pulier, but he’s done some amazing things throughout his life. This proud father of four is truly a gifted individual as he seems to excel in a wide variety of fields including technology, business, healthcare, and government. Eric Pulier is a man of many talents and his huge resume is a testament to this. Pulier has helped raise hundreds of thousands of dollars for start-up tech companies and venture capital funds. Many of these start-ups has gone on to be a huge success in their respected fields of work. The same goes for charity. Pulier has raised and donated tens of thousands of dollars to non-profit organization both home and abroad (See more information here).

Having such business savvy ideas, Pulier has invested in many prominent businesses such as eCompanies, Trident Capital, and Monitor Ventures. Technology seems to be running the world as we know it and this brilliant mind has used some of the most advanced technology for numerous projects. He developed a platform to where a live feed was used for the space shuttle years ago. This was unheard of at the time and it gave people a way to have live interactions with the actual astronauts. Pulier has used his innovations in wide array of field such as entertainment, community, space exploration, and government. He was chosen to build a platform known as “The Bridge To The 21st Century” for Bill Clinton’s 2nd Presidential Term and the event was a hit as spectators and members of congress attended. See:

As of today Mr. Pulier resides in Los Angeles. His track to success started in his hometown of Teaneck, New Jersey then on to Harvard University and finally California.

For more information please visit

Josh Verne, Successful Entrepreneur and Leader of People

Josh Verne is a rising star in the world of American business and entrepreneurs. Beginning as co-president of Home Line Furniture, he moved on to become co-founder and CEO of, an online business that deducts purchases directly from payroll. After selling to Global Analytics Holding in 2014, Verne founded FlockU, a content exchange for college students in 2016 and is CEO of that company as well.


With over 20 years experience as an entrepreneur, Verne is well versed in starting, expanding, and then selling businesses. He believes that true vision and the surest path to success is simply the ability to see what others don’t and then act on that information accordingly. Josh Verne believes that finding what inspires you the most and putting it to work is the best chance any entrepreneur has for success.


Verne’s business philosophy is straightforward and simple. He believes there are two very different types of people typically found in management jobs. There are leaders, and then there are bosses. Bosses have the power of their job title to demand respect, and can be counted on to always act in their own best interest. A leaders however, earns the respect of co-workers by putting them ahead of his own desires.


Verne believes that in an atmosphere of respect, working together towards a common goal is much easier to do than the other option. Someone has to be the leader, but it can be a fine line to walk. A boss may be able to demand respect, and insist on his will being followed but how dependable is “forced” respect? Much better to earn it by leading well, and being the kind of person others know they can call on for help or advice.


One firm policy of Verne’s is never obligate yourself to an idea or plan that is “win-lose.” If the plan isn’t a winner for the client, business and socially as well, then it needs to be re-worked until it is. According to Verne, if one never settles for less than a win on all sides, they have no choice but to come up with a plan that works when problems crop up. This kind of thinking is what puts Verne a cut above anyone else in business only for themselves.


Verne has another philosophy that makes very good sense. He believes that people have two ears and only one mouth for a reason, and when the ears are used to listen more, and the mouth to talk less, that is a recipe for success that’s hard to beat. The less said, the more people pay attention when you do speak.


Balance in all areas of life is a must for those who want to succeed. If your private life and health aren’t all they could be, it doesn’t matter how big your bank account is. It takes money to get along in today’s society, and when one doesn’t make enough they and their loved ones are the people who will suffer for it. That simple point comes down to one thing, balance promotes progress.


Passion is a big part of any successful venture. Of course, there are a lot of people out there who have no shortage of passion yet they fail in business anyway. The trick is to find the idea that makes you want to get out of bed in the morning. If not, your business may keep plodding along anyway, but chances are it will never grow to reach its full potential.